Definition Of Visceral Metastases In Prostate Cancer

In an utterly unsurprising finding reported last weekend at the asco meeting in chicago halabi et al.

Definition of visceral metastases in prostate cancer. In the present study we retrospectively examined visceral metastases of prostate cancer pca at our hospital. In late stages hepatic encephalopathy can ensue. Goodman ob jr flaig tw molina a et al. Metastatic involvement of the viscera in men with advanced castration resistant prostate cancer crpc has been poorly characterised to date.

Although less common than bone metastases in prostate cancer the presence of visceral soft tissue metastases is adversely prognostic in men with metastatic castration resistant prostate cancer mcrpc. Retrospective analyses of datasets from large phase iii randomized trials showed that men with visceral metastases appear to derive clinical benefit from second generation antiandrogens as. Visceral metastases are not a good thing for prostate cancer patients. Visceral lesions derived from liver and lymph nodes were found to express an angiogenic profile different from that of liver metastases alone with significant relative overexpression of the proangiogenic factor angiopoietin 2.

In the case of liver metastases the first symptom may be liver function abnormalities or pain due to stretching of the hepatic capsule. The proportion of men with metastatic prostate cancer who develop visceral metastases rose from 26 in 2009 to 40 in 2016 a study found. Extensive liver metastases can lead to jaundice and biochemical evidence of liver failure. Exploratory analysis of the visceral disease subgroup in a phase iii study of abiraterone acetate in metastatic castration resistant prostate cancer.

Loriot y fizazi k de bono js et al. Men with metastatic castration resistant prostate cancer have multiple treatment options and the expanding palate of available therapies renders careful patient selection imperative. Reported based on a meta analysis of data from nearly 4 000 patients in clinical trials for late stage prostate cancer that having visceral i e soft tissue prostate cancer metastasis is not a good thing at all. In the tax 327 phase iii trial men receiving docetaxel or mitoxantrone every 3 weeks.

In 359 crpc patients treated between june 2003 and december 2011 the frequency of radiologically detected visceral metastases before death was 32. Prostate cancer prostatic dis. Visceral metastases often present with organ dysfunction. Men with visceral especially hepatic metastases have a particularly poor prognosis regardless of the treatment selected.